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Metformin's chemical structurea biguanide with the formula CHNbears no structural similarity to controlled substances

The research group included corresponding author Anders Fink-Jensen of Copenhagen University Hospital, along with scientists from the United States National Institutes of Health

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Rare but more serious side effects include pancreatitis and hypoglycaemia when combined with insulin or sulfonylureas

As noted in recent research, further study is needed to determine whether these effects are maintained in the long-term

It is also contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [16]